The Koltsova Laboratory, led by Ekaterina Koltsova, MD, PhD, works to uncover immune-mediated mechanisms implicated to various immune-mediated pathologies such as atherosclerosis, abdominal aortic aneurysm (AAA), obesity and cancer. We are interested in understanding how distinct cytokines locally and systemically shape inflammatory environments during disease pathogenesis. In our research we work with models of atherosclerosis, abdominal aortic aneurysm and liver cancer, coupled with systemic and cell type-specific knockouts of cytokine receptors, to study the role of microbiota, microbiota-dependent metabolites and hematopoietic stem cell response to disease-related stress stimuli.