The Anastassiou Laboratory is affiliated with the Department of Neurosurgery and Neurology, the Center of Neural Sciences and Medicine and the Regenerative Medicine Institute. The Anastassiou Laboratory studies how the molecular and cellular composition of neurons translates to their phenotype and how these properties combine in brain circuits to produce function or, in the case of disease, dysfunction. The Anastassiou lab has broad background in multi-modal cellular data (electrophysiology, anatomy, transcriptomics) and the development of state-of-the-art computational workflows (statistical learning, optimization and simulation) to understand cellular activity in behavior and disease. Uniquely, this work includes human brain tissue, both as a byproduct from surgery as well as from model systems such as human pluripotent stem cells. The Anastassiou Lab successfully pursues collaborations with clinicians to translate cellular and circuit findings to better understanding of diseases such as epilepsy and Parkinson disease as well as development of improved therapies.